District Judge Liles Burke is a native of Marshall County, Alabama, the son of Claud and Sharon Burke, and Jane and the late Sid McDonald. He attended public schools in the City of Arab and then received his undergraduate degree from The University of Alabama in 1991. In 1994, he earned his law degree from The University of Alabama School of Law. While there, he served as the student member of The University of Alabama Board of Trustees, and was inducted as a member of Omicron Delta Kappa Honor Society and The Jasons.

He was admitted to practice in the Alabama Supreme Court and the U.S. Courts in 1994 and began the practice of law with his father in the firm then known as Burke & Beuoy, handling a wide variety of civil and criminal cases. He served as both Arab's Municipal Prosecutor and City Attorney during that time, and in 2001 was named the Municipal Judge for the City of Arab. He held that office until 2006 when he was appointed Marshall County District Judge by Governor Bob Riley. In 2008 Judge Burke was elected to a full term on the District Court, without opposition.

Judge Burke began Marshall County's first family drug court, and along with District Judge Tim Riley, implemented one of Alabama's first domestic violence courts. Additionally, he served as an officer in both the Alabama District Judges Association and the Alabama Juvenile Judges Association.

In February of 2011, Judge Burke was named by Governor Robert Bentley to a vacancy on the Alabama Court of Criminal Appeals.  He was elected to a six-year term in 2012 without opposition.  While on the Court of Criminal Appeals, he served as the President of the Alabama Appellate Judges Association.

Judge Burke has been active over the past many years in several charitable and community organizations, leading the Marshall County United Way fund drive, serving as President of the Arab Chamber of Commerce, and serving on the board of the Marshall County Healthcare Authority. He is Methodist, a Rotarian, and an alumnus of Leadership Alabama. Judge Burke holds the rank of Major in the Judge Advocate General's (JAG) Corps of the Alabama Army National Guard and is assigned to Joint Forces Headquarters in Montgomery, Alabama as the Deputy State Judge Advocate.

On July 17, 2017, President Trump nominated Judge Burke to be a United States District Judge for the Northern District of Alabama.  He was nominated to the seat vacated by Judge Charles Lynwood Smith, Jr., who took senior status on August 31, 2013.  He was confirmed by the U.S. Senate on October 11, 2018 and received his commission six days later.  Judge Burke currently serves as the resident District Judge at the Huntsville, Alabama United States Courthouse.

Judge Burke is married to the former Natalie Jones of Jasper, Alabama and they have two children.